Gonna flip on the seasons for me, either a blizzard or flooding/flash-flooding. Tied to both of those would be power outages, then the roads being blocked or washed out, respectively.
If non-natural disaster is also a consideration, economic collapse is the one that would probably be what I’d consider as the main one to worry about for me. That or some more basic financial things and trip ups, which would be more likely, tbh.