Where depends on the why.
Wildfire: I’d head toward a town an hours drive east of here to wait it out. Then hope to come home or at least camp on my land. Septic system and wells would still exist even if home were gone. I have 2 sons and good friends in that town. Most direct route is the interstate but in several places the old road that predated the interstate still exists and could be used to get around gridlock. There are places with no alternate and just the interstate crosses the country. It’s too rugged to take off cross country except on foot. At 72 and 82 and he has stage 6 of 7 Alzheimer’s, that isn’t an option. I’ve lived there but I hate cities. A town 20 miles west by the old road is also a possibility. There are no great friends but there are abandoned building and motels. There is a Wal-Mart that allows overnight in the parking lot. Certainly an easier place to get to. It’s half way to becoming a ghost town. There is also a KOA type campground with some amenities.
If it’s political. I head a little way West then north into the mountain above me. We live in the foothills. We could with determination walk across private properties but if we can drive there I’d take the 4×4 truck with its always full gas tank and a close by 5 gal gas can. Camping gear, bug out bags, important papers are all close if we have 5 minutes. If not the box in either the car or truck would give us 1 change of weather appropriate clothing, 2 blankets and food and water with mess kits for cooking to last a few days. The mountain has deer, elk, bear, big cats, wild turkeys and more. I know places with water and if still unfound I have caches on the mountain from when I was able to go hiking often. My preferred place is an almost unknown tiny ancient pit house ruin near a water seap. Well hidden after fording a rock bed stream that is safe to drive on. Only a short area where tracks would need to be hidden. My old motor home could easily hid there under a stand of trees. Or just build a new roof over the ancient dwelling. Short term or long term it would be my choice location if I can’t stay home. I’d take a bicycle to use to check out the situation around the mountain. There is a bench 3 miles above that with a spring where wild life goes for water. My bows and arrows are by the front door. Much quiter than guns. Snares and Forraging make for a more secure food supply. I’ve done it before with just one change of clothing, a pocket knife and half a book of paper matches. I made it for 10 months. It was a milder climate but still I spent many nights below freezing. Here -10 to -20 winter nights are to be reasonably expected. I love solitude and making things. If it were long term this would be My First Choice. If bugging out becomes a necessity.